Endocrine Abstracts

Introduction: Cytokine TNF-alpha has widespread metabolic actions, including induction of insulin resistance, lipolysis and cachexia. Systemic TNF-alpha administration, however, generates complex hormonal and metabolic scenario. No studies employing regional, placebo controlled TNF-alpha infusion exist. Our study was designed to test the hypothesis that local leg perfusion with TNF-alpha directly induces insulin resistance, lipolysis and protein breakdown.<p class="abstext...

Introduction: In humans bacterial lipopolysaccharide (LPS/endotoxin) causes chronic low-grade and acute inflammatory responses, which decrease insulin sensitivity and may lead to chronic type 2 diabetes and acute stress diabetes. Systemic LPS invariably generates cytokine release, which triggers release of anti-insulin stress hormones and it is not known whether insulin resistance is secondary to stress hormones or LPS per se. Our study was designed to test whether local place...